If you’re preparing for your first chemotherapy session, you’re likely feeling a mix of emotions—nervousness, uncertainty, and even a bit of hope. This is a big step in your cancer treatment journey, and while the unknown can feel overwhelming, knowing what to expect can provide some comfort and control. While every person’s experience is unique, there are many shared elements that can help you feel more prepared and less alone.
What Happens During the First Chemo Treatment?
Chemotherapy is a medical treatment that uses powerful drugs to target and destroy cancer cells. It’s often delivered in cycles, with rest periods in between to allow your body to recover. The first session usually involves a bit more time and conversation as your care team walks you through the process.
Arrival and Orientation
When you arrive for your first appointment, expect a brief check-in process, followed by a sit-down with your care team. They’ll explain what drugs you’re receiving, how long the treatment will take, and what side effects might occur. You may also have labs done to check your blood cell counts.
Pre-Treatment Medications
Many patients are given medications before the chemo begins to minimize potential side effects. These can include anti-nausea drugs, steroids, and allergy medications. These are often administered through an IV, but some might be taken orally.
Infusion and Monitoring
The actual chemotherapy drugs are typically delivered intravenously, though some may be taken as pills or injections. The infusion can take anywhere from 30 minutes to several hours. Nurses will monitor you for any reactions, answer your questions, and make sure you’re as comfortable as possible during the process.
What Should You Bring to Your First Appointment?
Preparing for a long session can help the time pass more easily and comfortably. Here are a few helpful items to consider:
- A blanket or warm clothing layers
- Books, a journal, or digital entertainment
- Water, light snacks, or electrolyte drinks
- Headphones or earplugs for quiet time
- A notebook with questions for your care team
Many patients also bring a friend or family member for support, especially during the first treatment. If your treatment center allows it, having a loved one present can ease anxiety and provide emotional grounding.
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How You Might Feel Immediately After Chemo
The hours and days following your first chemotherapy treatment can bring a variety of physical and emotional changes. Some people feel fine immediately after; others may begin to notice side effects within hours.
Common Side Effects in the First 24–72 Hours
- Fatigue: One of the most reported side effects. Many patients fel physically and mentally drained.
- Nausea and vomiting: Modern medications are effective, but some nausea may still occur.
- Changes in appetite or taste: Foods may taste metallic or bland, and your appetite might decrease.
- Increased sensitivity to smells: Strong scents may suddenly become overwhelming.
- Headaches or dizziness: These may result from medications, dehydration, or tension.
- Mild fever or chills: A low-grade fever is not uncommon but should be monitored closely.
It’s important to track how you’re feeling and notify your care team about any concerning symptoms.
Emotional Responses to the First Treatment
Chemotherapy affects more than just the body. It’s also a profound emotional experience. The first treatment often serves as a wake-up call—it confirms that the diagnosis is real and the fight has begun.
You Might Feel:
- Anxious or tense about what lies ahead
- Isolated, even if surrounded by loved ones
- Empowered, because you’re actively confronting the disease
- Exhausted by the emotional toll
All of these responses are completely normal. Journaling, support groups, therapy, or simply speaking with someone you trust can help you process these emotions and avoid feeling overwhelmed.
Caring for Yourself at Home
Recovery between treatments is critical. What you do in the days following chemo can impact your overall energy, immunity, and ability to manage future sessions.
Tips for Physical Self-Care
- Rest regularly: Your body is working hard. Don’t push yourself.
- Stay hydrated: Water, broths, and electrolyte drinks are key.
- Eat light but nutritious meals: Focus on foods that are easy to digest—soups, smoothies, whole grains, fruits, and vegetables.
- Avoid strong smells and greasy foods: These may trigger nausea.
Tips for Emotional and Mental Wellness
- Connect with others: Share how you’re feeling with friends, family, or a support group.
- Establish a routine: Even light structure can offer a sense of normalcy.
- Incorporate calming activities: Meditation, deep breathing, and light stretching can ease anxiety.
- Celebrate small victories: Completing your first treatment is an accomplishment.
What Items Can Support Post-Chemo Recovery?
Having supportive, comforting items nearby can make recovery a bit easier. Consider gathering the following:
- Unscented lotion and lip balm for dry skin
- A thermometer to monitor fever
- A soft-bristle toothbrush and gentle mouth rinse
- Light snacks
- Loose-fitting clothing to stay comfortable
- Pre-made meals or meal delivery options
How to Support a Loved One Going Through Their First Chemo
If you’re a caregiver, friend, or family member, your role is powerful. Your presence, attentiveness, and patience can make a huge impact. Here are a few ways to support someone after their first treatment:
- Offer to drive them to appointments or run errands
- Prepare easy meals or help with small chores
- Sit and listen—sometimes, just being there is enough
- Avoid offering advice unless asked
- Respect their energy levels and mood shifts
Sending a chemo care package can also be a thoughtful gesture. It not only provides useful items but also sends the message: “You’re not alone.”
Final Thoughts: Taking the First Step with Strength
Your first chemotherapy treatment is an important milestone. It may bring challenges, but it also brings progress. You’re not just undergoing treatment—you’re actively fighting back. Every session is a step forward, even on days when it feels like a struggle.
Remember: healing is not linear. There will be good days and hard days, and that’s okay. With preparation, support, and the right tools, you can navigate this journey with resilience and grace.
At Rock The Treatment, we’re here to help patients feel seen, supported, and cared for. Whether it’s through comfort-focused gift baskets or helpful resources like this, we believe in walking alongside every person facing cancer—with strength, dignity, and heart.
I start chemo in 4 days and I’m scared. Your article did help to know what to expect. I appreciate that. I’ve had some complications that aren’t helping but one day at a time. No one really to talk to so thanks for listening.
I’m going to start my chemo shortly. Anything that surprised you that you wished you had known?
That’s such a good question. Everyone’s experience is different, but something many people tell us is that they were surprised by how much the little comforts matter—soft socks, lip balm, gentle lotions, and things to help pass the time like journals or puzzle books. Staying hydrated and having snacks that are easy on the stomach can also make a big difference.
Most of all, give yourself grace—some days will feel harder than others, and that’s okay. Lean on your support system, and don’t be afraid to ask for help with even the small things.
I start cemotherpy 1-6-26 I am very frightened & nervous
I just got my port put in my chest I’m totally petrified I’m scared,don’t know what to expect don’t even know my feelings right now,but I’m going in head first an healed up high,I guess when my first chemo treatment is done I know then that it is real thank you
Getting a port placed makes everything feel so real, and it’s completely okay to feel scared and unsure right now. Anyone would.
But I also hear your strength — going in head first with your head held high? That’s courage, even if your heart is shaking.
One step, one treatment, one breath at a time. And when that first chemo is done, you’ll know something important: you did it.
You’re stronger than you think — and you’re not alone.
I’m so sorry for the late reply. Thank you for sharing your heart—it means so much. Starting chemo is such a huge step, and it’s normal to feel scared. One day at a time really is the best approach. Please know you’re not alone—we’re thinking of you and sending strength for your treatment journey.
I get my port on April 2nd then I start Chemo on the 14th I am scared. this is my 2nd time with Cancer 18 years ago I had Galdblader cancer I had chemo 6days a week 24 hours a day I carried it like a purse. I had no reaction to it at all other than a blood clot in my neck. I have been Cancer free since 5/25/08 for a Cancer which I was most likely to die from yesterday I was in a research program.
this time I was also in a research program but it only shrank the tumor in half so I have to do 4 chemo treatment 3 weeks apart 3 hours long then radiation. please pray fir me.
It makes so much sense that you’re scared! This is a lot to face. But you have also showed incredible strength and resilience. You’ve already overcome so much, that is the same strength that is still with you now. You’re not alone in this, the ROCK the TREATMENT team is sending you so much love and support as you move through each step. 💛
I am starting chemo Tuesday the 6th of Dec. I’m not scared at all. The less scared you are the more your body fights! you’ve got this an I’ve got this!!!! We can fight this Denise 💪 I also realize how much power our God has and give all your worries to him! Look nothing worth fighting is going to come with some lows. But when you have the highs it makes you stronger!! If you would like I will talk to you when you’re feeling down honey. Just email me.
How has your treatments and the fight back going?
Thank you for this. Today will be my first treatment so many emotions at once.
Sending you so much strength today as you begin your first treatment. It’s natural to feel so many emotions all at once—you’re not alone in that. Lean on your faith, your support system, and your own resilience. One step at a time, you’ve got this.
My first treatment is tomorrow, and this info has been such a comfort…also knowing that many of you have the same questions and fears as me. Giving my fears to God and gonna get a good night’s sleep! ❤️
What a beautiful way to walk into treatment placing your fears in God’s hands. We are also praying He surrounds you with peace tonight and carries you through every moment of your treatment. You are covered in strength and love. 🙏💛
I begin my first treatment on September 11 and I just happened to google about information and found this page and it was very helpful and useful I have had questions about totally being on 100%but I feel better than I am making the decision nessary for my continued life I have a very supportive family and strong faith
Thank you so much for sharing this. Starting treatment is such a big step, and it sounds like you’re walking into it with courage, strong faith, and a supportive family by your side—that makes all the difference. We’re sending you strength, comfort, and blessings as you begin on September 11. You are not alone. 💜🙏
Praise God I’m going to my Dr appointment tomorrow. So I don’t know when I’ll start but my faith is God will see me through. Prayers for you all 🙌🏼🙏 any and all tips are welcome Thank you!
We’ll be keeping you in our prayers tomorrow as you head to your appointment. Your faith is truly inspiring, and we believe right along with you that God will carry you through this. One step, one day at a time—you are not alone in this journey. Thank you for sharing your strength, and please know we’re sending you love, prayers, and encouragement always.
thank you, my 1st is tomorrow and im trying to stay strong for my family as well as myself In Jesus Mighty Name
We wish you strength, courage and BLESSINGS!!!!!!!
Wonderful article..thank you..my first treatment is tomorrow…I’m feeling very anxious but God Will get me thru,AMEN…thanks for all the info.
Wishing you peace of mind and so many prayers and blessings.
Thank you so much for sharing this. Starting treatment is such a big step, and it’s completely normal to feel a mix of emotions. It’s wonderful that you have a strong support system and faith to lean on—that makes such a difference. Please know you’re not alone on this journey, and we’re wishing you strength, comfort, and healing as you begin on September 11. One day, one step, one moment at a time.
I just finished my first chemo treatment yesterday last night I was emotional my breathing was hard woke up this morning n I’m not to bad
Thank you so much for sharing what you’re going through. The first treatment can stir up so many emotions, and it’s completely normal to feel both overwhelmed and relieved once it’s behind you. I’m glad to hear today is feeling a little lighter than last night. Be gentle with yourself as your body adjusts—you’re showing so much strength just by taking it one step, one day at a time.
You’re not alone in this. Sending you comfort, healing, and hope as you continue your journey.
Had my first round this week not as bad as I anticipated the nurses were great. I am a little fatigued thy morning but blessed want to get through this journey.
Marla, we are so glad the first treatment was smooth and the staff was excellent. Wishing g you many blessings.
Had my first treatment yesterday, felt overwhelmed but the nurses are so reassuring and makes you feel loved. First treatment was like nothing, no side affects. Got shot today for white blood cells. So far, so good. Take one day at a time.
One day at a time is exactly right. We are cheering you on and sending you continued strength and gentle healing every step of the way. Blessings.
I’m so glad I found this group! I’ve actually been in treatment for gastrointestinal cancer with oral medications for 2 1/2 years and they all had the same side effects that I hear chemotherapy has. In June I had a complete hysterectomy to remove uterine cancer- leiomayosarcoma and even though that was a success the cancer went to my lungs. I am getting a port installed tomorrow and I start chemo next Tuesday. I’ve felt very positive throughout all of this and I’m lucky to have such a great support system.
My partner is worried about how I’ll feel after chemo-I’m usually really cheerful and fun so he’s concerned I’ll feel awful. After being on oral meds this long I don’t know if there will be much of a difference but I’ll have to find out myself.
Good luck to you all and wishing you swift healing and recovery 💜
Started My first Chemotherapy today. A bit of a headache but doing well otherwise.
Wishing you SO MANY BLESSINGS!!!!
As I start on my journey tomorrow morning these articles did ease my mind , not knowing what to expect. It is a scary feeling not knowing. God Bless us all who are fighting this monster .🙏🏻❤️🙏🏻
We are so glad the articles brought you comfort — sending you strength, peace, and many prayers. God bless you always.
As I start on my journey tomorrow morning these articles did ease my mind , not knowing what to expect. It is a scary feelin. God Bless us all who are fighting this monster .🙏🏻❤️🙏🏻
We are so glad the articles brought you comfort — sending you strength, peace, and many prayers. God bless you always.
Reading all your notes helping me a great deal. God bless you all on winning your fight
I’ll be starting chemo soon. Curious, when to expect hair loss .
I have my first chemo for breast tomorrow and am afraid I will lose my identity and will never be the same
I’m starting tomorrow too.i feel the same
It’s completely normal to feel this way before treatment. We are really glad you found some comfort here in knowing you’re not alone. Focus on resting and taking things—one step at a time. You’ve got this. 💛
I had my first treatment on this past Thursday. I felt great after treatment and on Friday. It’s Saturday and I’m feeling fatigued and hungry. I’m also feeling emotionally taxed. My family is here but I feel lonely. Physically, I’m feeling pretty good. Mentally, I’m a bit overwhelmed by the unknown. Remaining positive…This too shall pass.
Thank you for your honesty. The unknown can feel heavy, even on “good” days. Sending you strength, calm, and continued healing—one step at a time.
I am scheduled for my first chemo treatment Wednesday …. 5 hours…every two weeks for 6 months. Am scared and excited at the same time. Scared of the side effects and excited to get started fighting this thing. Heard to help boost my immunity with antioxidants so I got a juicer . Juicing, turmeric, ginger, carrots, celery, parsley, appleand lemon peel… hopefully that’ll help… I have lots of support but I still go into my closet and cry. Reading all the comments helps…..ALOT!!! Thx!!!!
Very helpful and informative
Not sure my treatment yet
I’m very nervous and anxious. I just want to be healed in Jesus’ name and I’m ready to do whatever it takes to get me well.
We are so sorry you’re feeling this scared and overwhelmed. Please know you are not alone — we are holding you in prayer and believing for your strength, comfort, and healing. Be gentle with yourself and take this one moment at a time.
Starting chemo March 30. Had double mastectomy on February 17. Am almost 80 years old so worried if I can handle it at my age.
You’ve already been through so much, and your strength truly shows. It’s completely understandable to feel worried—but age doesn’t define your resilience. Take this one step at a time, and be gentle with yourself. The ROCK the TREATMENT team is sending you so much strength and comfort as you begin. Blessings
Starting chemo and immunology therapy on Friday not something I’m looking forward to but I will somehow give it a100%effort.
You don’t have to feel ready to be strong…you already are. Just showing up and giving it your all is everything. One step at a time, one day at a time. The ROCK the TREATMENT team is rooting for you and sending strength your way. 💛
Im on my way to my first treatment now and I’m scared. I feel more comfortable after reading this article because I remembered to bring a lot of things you mentioned. The battle is on but I’m going to win the war!!!!
Showing up even through the fear. That’s real courage. You’ve got everything you need, and you are stronger than you feel in this moment. One step at a time… and yes, you are absolutely going to win this war. 💛
Hi,
Received my port today, I start chemo tomorrow. I am healed by his stripes, and I am standing on his word.
Standing with you in faith and believing in complete healing. “By His stripes we are healed.” Praying for strength, protection, and peace as you begin chemo tomorrow. You are covered in love and grace. 🙏