If you’re preparing for your first chemotherapy session, you’re likely feeling a mix of emotions—nervousness, uncertainty, and even a bit of hope. This is a big step in your cancer treatment journey, and while the unknown can feel overwhelming, knowing what to expect can provide some comfort and control. While every person’s experience is unique, there are many shared elements that can help you feel more prepared and less alone.
What Happens During the First Chemo Treatment?
Chemotherapy is a medical treatment that uses powerful drugs to target and destroy cancer cells. It’s often delivered in cycles, with rest periods in between to allow your body to recover. The first session usually involves a bit more time and conversation as your care team walks you through the process.
Arrival and Orientation
When you arrive for your first appointment, expect a brief check-in process, followed by a sit-down with your care team. They’ll explain what drugs you’re receiving, how long the treatment will take, and what side effects might occur. You may also have labs done to check your blood cell counts.
Pre-Treatment Medications
Many patients are given medications before the chemo begins to minimize potential side effects. These can include anti-nausea drugs, steroids, and allergy medications. These are often administered through an IV, but some might be taken orally.
Infusion and Monitoring
The actual chemotherapy drugs are typically delivered intravenously, though some may be taken as pills or injections. The infusion can take anywhere from 30 minutes to several hours. Nurses will monitor you for any reactions, answer your questions, and make sure you’re as comfortable as possible during the process.
What Should You Bring to Your First Appointment?
Preparing for a long session can help the time pass more easily and comfortably. Here are a few helpful items to consider:
- A blanket or warm clothing layers
- Books, a journal, or digital entertainment
- Water, light snacks, or electrolyte drinks
- Headphones or earplugs for quiet time
- A notebook with questions for your care team
Many patients also bring a friend or family member for support, especially during the first treatment. If your treatment center allows it, having a loved one present can ease anxiety and provide emotional grounding.
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How You Might Feel Immediately After Chemo
The hours and days following your first chemotherapy treatment can bring a variety of physical and emotional changes. Some people feel fine immediately after; others may begin to notice side effects within hours.
Common Side Effects in the First 24–72 Hours
- Fatigue: One of the most reported side effects. Many patients fel physically and mentally drained.
- Nausea and vomiting: Modern medications are effective, but some nausea may still occur.
- Changes in appetite or taste: Foods may taste metallic or bland, and your appetite might decrease.
- Increased sensitivity to smells: Strong scents may suddenly become overwhelming.
- Headaches or dizziness: These may result from medications, dehydration, or tension.
- Mild fever or chills: A low-grade fever is not uncommon but should be monitored closely.
It’s important to track how you’re feeling and notify your care team about any concerning symptoms.
Emotional Responses to the First Treatment
Chemotherapy affects more than just the body. It’s also a profound emotional experience. The first treatment often serves as a wake-up call—it confirms that the diagnosis is real and the fight has begun.
You Might Feel:
- Anxious or tense about what lies ahead
- Isolated, even if surrounded by loved ones
- Empowered, because you’re actively confronting the disease
- Exhausted by the emotional toll
All of these responses are completely normal. Journaling, support groups, therapy, or simply speaking with someone you trust can help you process these emotions and avoid feeling overwhelmed.
Caring for Yourself at Home
Recovery between treatments is critical. What you do in the days following chemo can impact your overall energy, immunity, and ability to manage future sessions.
Tips for Physical Self-Care
- Rest regularly: Your body is working hard. Don’t push yourself.
- Stay hydrated: Water, broths, and electrolyte drinks are key.
- Eat light but nutritious meals: Focus on foods that are easy to digest—soups, smoothies, whole grains, fruits, and vegetables.
- Avoid strong smells and greasy foods: These may trigger nausea.
Tips for Emotional and Mental Wellness
- Connect with others: Share how you’re feeling with friends, family, or a support group.
- Establish a routine: Even light structure can offer a sense of normalcy.
- Incorporate calming activities: Meditation, deep breathing, and light stretching can ease anxiety.
- Celebrate small victories: Completing your first treatment is an accomplishment.
What Items Can Support Post-Chemo Recovery?
Having supportive, comforting items nearby can make recovery a bit easier. Consider gathering the following:
- Unscented lotion and lip balm for dry skin
- A thermometer to monitor fever
- A soft-bristle toothbrush and gentle mouth rinse
- Light snacks
- Loose-fitting clothing to stay comfortable
- Pre-made meals or meal delivery options
How to Support a Loved One Going Through Their First Chemo
If you’re a caregiver, friend, or family member, your role is powerful. Your presence, attentiveness, and patience can make a huge impact. Here are a few ways to support someone after their first treatment:
- Offer to drive them to appointments or run errands
- Prepare easy meals or help with small chores
- Sit and listen—sometimes, just being there is enough
- Avoid offering advice unless asked
- Respect their energy levels and mood shifts
Sending a chemo care package can also be a thoughtful gesture. It not only provides useful items but also sends the message: “You’re not alone.”
Final Thoughts: Taking the First Step with Strength
Your first chemotherapy treatment is an important milestone. It may bring challenges, but it also brings progress. You’re not just undergoing treatment—you’re actively fighting back. Every session is a step forward, even on days when it feels like a struggle.
Remember: healing is not linear. There will be good days and hard days, and that’s okay. With preparation, support, and the right tools, you can navigate this journey with resilience and grace.
At Rock The Treatment, we’re here to help patients feel seen, supported, and cared for. Whether it’s through comfort-focused gift baskets or helpful resources like this, we believe in walking alongside every person facing cancer—with strength, dignity, and heart.
I start chemo in 4 days and I’m scared. Your article did help to know what to expect. I appreciate that. I’ve had some complications that aren’t helping but one day at a time. No one really to talk to so thanks for listening.
I’m going to start my chemo shortly. Anything that surprised you that you wished you had known?
That’s such a good question. Everyone’s experience is different, but something many people tell us is that they were surprised by how much the little comforts matter—soft socks, lip balm, gentle lotions, and things to help pass the time like journals or puzzle books. Staying hydrated and having snacks that are easy on the stomach can also make a big difference.
Most of all, give yourself grace—some days will feel harder than others, and that’s okay. Lean on your support system, and don’t be afraid to ask for help with even the small things.
I’m so sorry for the late reply. Thank you for sharing your heart—it means so much. Starting chemo is such a huge step, and it’s normal to feel scared. One day at a time really is the best approach. Please know you’re not alone—we’re thinking of you and sending strength for your treatment journey.
Thank you for this. Today will be my first treatment so many emotions at once.
Sending you so much strength today as you begin your first treatment. It’s natural to feel so many emotions all at once—you’re not alone in that. Lean on your faith, your support system, and your own resilience. One step at a time, you’ve got this.
I begin my first treatment on September 11 and I just happened to google about information and found this page and it was very helpful and useful I have had questions about totally being on 100%but I feel better than I am making the decision nessary for my continued life I have a very supportive family and strong faith
Thank you so much for sharing this. Starting treatment is such a big step, and it sounds like you’re walking into it with courage, strong faith, and a supportive family by your side—that makes all the difference. We’re sending you strength, comfort, and blessings as you begin on September 11. You are not alone. 💜🙏
Praise God I’m going to my Dr appointment tomorrow. So I don’t know when I’ll start but my faith is God will see me through. Prayers for you all 🙌🏼🙏 any and all tips are welcome Thank you!
We’ll be keeping you in our prayers tomorrow as you head to your appointment. Your faith is truly inspiring, and we believe right along with you that God will carry you through this. One step, one day at a time—you are not alone in this journey. Thank you for sharing your strength, and please know we’re sending you love, prayers, and encouragement always.
Thank you so much for sharing this. Starting treatment is such a big step, and it’s completely normal to feel a mix of emotions. It’s wonderful that you have a strong support system and faith to lean on—that makes such a difference. Please know you’re not alone on this journey, and we’re wishing you strength, comfort, and healing as you begin on September 11. One day, one step, one moment at a time.
I just finished my first chemo treatment yesterday last night I was emotional my breathing was hard woke up this morning n I’m not to bad
Thank you so much for sharing what you’re going through. The first treatment can stir up so many emotions, and it’s completely normal to feel both overwhelmed and relieved once it’s behind you. I’m glad to hear today is feeling a little lighter than last night. Be gentle with yourself as your body adjusts—you’re showing so much strength just by taking it one step, one day at a time.
You’re not alone in this. Sending you comfort, healing, and hope as you continue your journey.
Had my first round this week not as bad as I anticipated the nurses were great. I am a little fatigued thy morning but blessed want to get through this journey.
Marla, we are so glad the first treatment was smooth and the staff was excellent. Wishing g you many blessings.